Browsing: Critical Care Alert

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Critical Care , Critical Care Alert

Critical Care Alert: Prevention of Early Ventilator-Associated Pneumonia After Cardiac Arrest

4/21/2020 Sarah Ring, MD , Sean M. Hickey, MD
Can prophylactic antibiotics affect the incidence of ventilator-associated pneumonia following out-of-hospital cardiac arrest?
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Critical Care , Critical Care Alert

Critical Care Alert: Hydrocortisone, Thiamine, and Vitamin C in Septic Shock

2/17/2020 Greg Felock, MD , Sean M. Hickey, MD
The VITAMINS Trial looked at the role of vitamin C, thiamine, and hydrocortisone in saving patients with septic shock. It's the first randomized controlled trial focused on whether vitamins can provid
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Critical Care , Critical Care Alert

Critical Care Alert: Conservative Oxygen Therapy in Mechanically Ventilated Patients - the ICU-ROX Study

2/10/2020 Melissa Villars, MD, MPH , Sean M. Hickey, MD
The ICU-ROX study, designed as the largest RCT of mechanically ventilated ICU patients, investigates whether conservative oxygen therapy could reduce mortality. Are the results enough to tip the scale
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Critical Care , Critical Care Alert

Critical Care Alert: Epinephrine for Out-of-Hospital Cardiac Arrest

1/10/2020 Melissa Villars, MD, MPH , Sean M. Hickey, MD
This review article was trying to take another look at the impact of epinephrine, especially its impact on meaningful neurologic survival, to see if the debates launched by the PARAMEDIC-2 trial were
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Critical Care , Critical Care Alert

Critical Care Alert: Reviewing the Evidence for CITRIS-ALI Study

1/3/2020 Melissa Villars, MD, MPH , Sean M. Hickey, MD
Can vitamin C benefit patients with sepsis-related ARDS? Take a look at the evidence from the CITRIS-ALI study before you take a stance in this ongoing debate.
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Critical Care , Critical Care Alert

Critical Care Alert: Medications for Status Epilepticus - The ESETT Trial

12/23/2019 Melissa Villars, MD, MPH , Sean M. Hickey, MD
Sometimes a clinical trial shows no statistical differences yet can help to illuminate best practices. Count the ESETT Trial as one of them.
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Critical Care , Critical Care Alert

Critical Care Alert: Targeted Temperature Management for Cardiac Arrest with Non-shockable Rhythm - The HYPERION Trial

12/19/2019 Joshua Novy, MD, MBA, MS , Sean M. Hickey, MD
Moderate therapeutic hypothermia could be another tool in treating cardiac arrest patients. But how much should a patient be cooled? The HYPERION Trial doesn't resolve that debate.
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Critical Care , Critical Care Alert

Critical Care Alert: CRASH-3 Review of TXA for TBI

12/16/2019 Ryan Lee, MD , Raymond Green, DO, FACS , Michael Perza, PharmD, BCPS
Released in October 2019, CRASH-3 is the latest trial exploring the benefits of tranexamic acid, this time in traumatic brain injury. The bottom line: TXA hasn't been shown to reduce mortality.
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Critical Care , Critical Care Alert

Critical Care Alert: Reviewing the Evidence for SEP-1

10/9/2019 Omid Manoochehri, MD , Sean M. Hickey, MD
The SEP-1 core measure instituted by CMS has been hotly debated. A new review of literature shows a lack of high-quality evidence to back up the specificity required in the sepsis bundle.
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Critical Care , Critical Care Alert

Critical Care Alert: The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS)

8/12/2019 Joshua Novy, MD, MBA, MS , Sean M. Hickey, MD
Fluid resuscitation guidelines for severe sepsis and septic shock presently address only the initial phase of resuscitation. The RIFTS trial examines the efficacy of a restrictive IV fluid resuscitati