Buprenorphine has been shown to be a safe and effective medication in multiple settings with extensive research on both unobserved induction and physician-observed induction. Emerging evidence suggest

At toxic doses, tricyclic antidepressants (TCAs) cause blockade of sodium channels, muscarinic receptors, and alpha-adrenergic receptors. Slowed ventricular contraction, tachycardia, and vasodilation